Genetic Constructor

The Genetic Constructor Support Hub

Welcome to the Genetic Constructor developer hub. You'll find comprehensive guides and documentation to help you start using and extending the Genetic Constructor as quickly as possible, as well as support if you get stuck. Let's jump right in!

Documentation    Support

Welcome

to the Genetic Constructor Documentation

Here you'll find tips and tricks to help you design with Genetic Constructor. Read below for a quick overview or use the navigation and search bar explore other topics.

If you can't find the answer to your question here,
please visit the support page !

A New Approach to Genetic Design

Every masterpiece begins as a sketch. Just like an artist, a genetic designer starts by thinking and experimenting at a high level - adding the details later. Genetic constructor allows you to skip the whiteboard and forget the sequence editors you are used to. You can go straight to your web browser to begin crafting your masterpiece.

You can:

  • Sketch - Begin a design by sketching its intent. For example, a strong promoter driving a gene in a specific genetic context.
  • Import - After sketching, you can attach your genetic sequence data. Do this easily by importing from popular databases like NCBI and iGEM, or from your own library.
  • Create Combinatorial Libraries - Test hundreds of gene combinations in a single design by building your own libraries.
  • Share - Share all of your designs easily with your colleagues.

Sketch

Drag and drop from a library of SBOL operators to sketch and design your constructs. You can focus on the function and your final design intent - leaving sequences for later.

Simply drag & drop components to sketch your construct

Simply drag & drop components to sketch your construct

Import

Once you've sketched your design, you can search for your favorite gene in a database such as NCBI - then drag it straight into your project.

Or, you can import from your local files in either csv format or GenBank format to create your custom building blocks on the fly.

Search for Runx1 in NCBI and drag&drop it onto your CDS block to add the saved sequence to it.

Search for Runx1 in NCBI and drag&drop it onto your CDS block to add the saved sequence to it.

Create Combinatorial Libraries

Want to test a promoter library and a tag library with your favorite gene?

With Genetic Constructor, you can use List Blocks to store lists of possible sequences. This allows you to preview many combinations with a single design.

In this example the promoter, CDS and terminator contain list blocks. Once the csv is uploaded, the options appear in their respective block. The sequence viewer (at the bottom of the screen) will show the active option - this can be easily toggled while viewing with the sequence updating live.

In this example the promoter, CDS and terminator contain list blocks. Once the csv is uploaded, the options appear in their respective block. The sequence viewer (at the bottom of the screen) will show the active option - this can be easily toggled while viewing with the sequence updating live.

Share

You can export and import your projects as GenBank files to share with your colleagues - or to use with other tools. There are also more publishing options on the way.

Download whole projects, individual constructs, and combinatorial constructs

Download whole projects, individual constructs, and combinatorial constructs

Video Tutorial

Welcome

to the Genetic Constructor Documentation